1 p.m., CBS
MATCHUP to watch
Eli Manning vs. Bills’ secondary
Interceptions have not been nearly as great an issue for the Giants this season as they were in 2010, but if ever there was a game for a relapse, this would be it. The Bills have 12 interceptions (and 16 takeaways over all), with safety George Wilson recording an interception each of the last three weeks. On Sept. 25, Tom Brady threw four interceptions against the Bills, so Manning must beware.
NUMBER to watch
Say this for the Giants and Bills: They don’t pass up opportunities to score. In 20 trips inside the opponents’ 20 this season, the Bills have scored 15 touchdowns, giving them the N.F.L.’s best red-zone efficiency at 75 percent. Right behind them? The Giants, who have scored 10 touchdowns in 14 red-zone opportunities (71 percent).
QUOTATION OF THE WEEK
‘Fitz is finding everybody — we all want to get into the stands and celebrate with the fans.’
Bills receiver STEVIE JOHNSON, on quarterback Ryan Fitzpatrick’s accuracy in the red zone.